Spinal Cord Injury

Biomarkers for Recovery Following Spinal Cord Injury

adomenighe — Mon, 04 Mar 2024 20:40:24 +0000

Biomarkers for Recovery Following Spinal Cord Injury

adomenighe Mon, 03/04/2024 - 14:40 ProjectBiomarkers for Recovery Following Spinal Cord Injury /research/labs/translational-biomedicine-lab/projects/biomarkers-recovery-following-spinal-cord-injuryproject-type--spinal-cord-injury

Our laboratory is proud to collaborate with Dr. Monica Perez and her Team on a clinical study focused on spinal cord injury (SCI) within the Spinal Cord Injury Model System. This collaborative effort spans five hospitals nationwide, including the Shirley Ryan С�� (Lead site), Craig Hospital, Baylor Scott and White Health, University of Minnesota, Allina Health, and the Mayo Clinic. Our role in this study involves providing support for blood processing and conducting analyses on circulating Brain-Derived Neurotrophic Factor (BDNF) and genetic polymorphisms. We aim to investigate the relationship between BDNF and spasticity severity in individuals with motor complete SCI.

GO BACK

Monica A. Perez, PT, PhD

Scientific Chair, Arms + Hands Lab, Shirley Ryan С�� | Professor of Physical Medicine and Rehabilitation, Northwestern University

March 04, 2024

Posted By Andy Domenighetti

Project Type

Spinal Cord Injury, Biology

Facets for Clinicians and Researchers

Research Labs & Centers

Using a Health Technology Assessment Framework for Evaluating the Utilization and Efficiency of Wearable Exoskeleton for Spinal Cord Injury Rehabilitation

sparmet — Mon, 12 Jun 2023 15:40:24 +0000

Using a Health Technology Assessment Framework for Evaluating the Utilization and Efficiency of Wearable Exoskeleton for Spinal Cord Injury Rehabilitation

sparmet Mon, 06/12/2023 - 10:40 ProjectUsing a Health Technology Assessment Framework for Evaluating the Utilization and Efficiency of Wearable Exoskeleton for Spinal Cord Injury Rehabilitation /research/labs/cror/projects/using-health-technology-assessment-framework-evaluating-utilization-and-efficiency-wearableproject-type--spinal-cord-injury

Robot-assisted therapy (RT) is used increasingly as a treatment to improve walking after SCI; the field has seen sustained, rapid growth over the past decade. While RT was expected to provide enhanced benefits over more labor-intensive, less controlled motor learning strategies, so far, it has not demonstrated greater effectiveness than conventional therapy in improving function in patients with a range of neurological conditions. Where some investigators are calling for RT to “trot back to the starting gate” due to its lack of superiority over standard care with respect to functional gains, an alternative scenario that could make RT an attractive supplement to conventional therapy is one in which RT provides similar patient benefits at a lower cost. Indeed, one of the main arguments supporting the continued use and development of RT in rehabilitation has been the assumption that cost savings would be achieved by reducing labor costs.

What is the goal of this project?

The goal of this collaborative module was to obtain evidence that informs consumers, clinicians, insurers, and manufacturers about the utilization and cost-effectiveness of robotic exoskeletons in inpatient, outpatient, and community settings.

Aims of the project are to:

Describe the physical, psychological, demographic, and socio-economic characteristics, and insurance coverage of patients who receive RT-exo therapy
Compare the treatment goals and outcomes of patients who receive RT-exo therapy vs. conventional therapy in terms of functional goals and targeted impairments using performance-based measures (motor strength, endurance, gait characteristics), and patient-reported outcomes stratified by injury level, completeness, and chronicity.
Evaluate the cost effectiveness and budget impact of RT-exo therapy vs. conventional therapy to the individual, the health care system, and society.

Findings will inform clinical practice, guide commercial development of rehabilitation robots for human mobility, and assist in planning of clinical trials.

What are some of the results?

This project has completed.

Some of the findings have been reported in a 2023 paper in the Journal of NeuroEngineering and Rehabilitation, "Cost-effectiveness analysis of overground robotic training versus conventional locomotor training in people with spinal cord injury."

Conventional locomotor training includes treadmill-based training using assistive devices or track-based systems with harnesses and integrated safety systems where therapists manually facilitate stepping. Multiple therapists are often required ensure patient safety and provide support, making this kind of therapy labor intensive for clinicians. Robotically-assisted locomotor therapy includes both treadmill-mounted powered assistive technology as well as stand-alone exoskeletons that can be attached to the patient’s body to facilitate motion. These devices allow the patient to take more steps per session than conventional therapy and lessen the labor needed by therapists.

The researchers estimated cost of locomotor therapy and examined data on improvement in quality adjusted life years for 99 patients with SCI undergoing locomotor training at four SCI Model Systems locations: Shirley Ryan С��, Craig Hospital in Englewood, Colorado, Shepherd Center in Atlanta and TIRR Memorial Hermann in Houston. Participants were on average 39 years old, 4.8 years post-injury during the study period and 20 percent had a complete SCI.

Complete spinal cord injuries result in paralysis below the level of injury. Incomplete spinal cord injuries result in partial damage to the spinal cord and movement depends on the location and severity of the injury.

Costs were lower for conventional training ($1758) versus robotic training ($3952), and were lower for patients with incomplete versus complete SCI. Overall, the researchers found that the most cost-effective locomotor training strategy for people with SCI differed based on the completeness of their injury. Robotic training was more cost-effective than conventional training for people with complete SCI while traditional training was more cost-effective for people with incomplete SCI.

“Based on current knowledge, it makes sense that full, lower-body robotic exoskeleton-supported physical therapy is more cost effective for patients with complete spinal cord injuries,” said Arun Jayaraman, PhD, Director of the Max Näder Center for Rehabilitation Technologies and Outcomes Research at Shirley Ryan С�� and a co-author on the paper. “Realizing that these devices are impactful in this more severely impaired population, researchers should focus on modular and soft wearable robots to enhance therapy outcomes in the future.”

Arun Jayaraman, PT, PhD

Executive Director, Technology & Innovation Hub (tiHUB); Director, Max Näder Center for Rehabilitation Technologies & Outcomes Research

Allen Heinemann, PhD

Director, Center for Rehabilitation Outcomes Research Professor, Department of PM&R, Feinberg School of Medicine, Northwestern

June 12, 2023

Project Type

Spinal Cord Injury

Facets for Clinicians and Researchers

Research Labs & Centers

Patient Engagement Intervention in Inpatient Spinal Cord Injury Rehabilitation

sparmet — Mon, 30 Jan 2023 16:54:44 +0000

Patient Engagement Intervention in Inpatient Spinal Cord Injury Rehabilitation

sparmet Mon, 01/30/2023 - 10:54 ProjectPatient Engagement Intervention in Inpatient Spinal Cord Injury Rehabilitation /research/labs/cror/projects/patient-engagement-intervention-inpatient-spinal-cord-injury-rehabilitationproject-type--spinal-cord-injury

Background: Engaging patients in therapy is vital in rehabilitation, particularly for patients admitted into inpatient spinal cord injury (SCI) rehabilitation. Literature demonstrates that patients who have higher engagement in therapy tend to have greater functional independence. Certain skills used by occupational or physical therapists may improve patient engagement in therapy (e.g., skills to identify goals that are important to each patient, speaking in a manner that the patient can understand). To ensure that therapists learn and utilize these skills, we have developed a treatment intervention called Enhanced Medical Rehabilitation (EMR). The goal of EMR is to teach therapists a set of behavioral skills so that (1) therapy sessions are patient directed, (2) patients are more active in therapy, and (3) therapists provide more feedback to patients. We previously showed that EMR works to improve outcomes for older adults in nursing facilities. We do not yet know whether EMR works well in inpatient SCI units; thus, we decided to use a well-known adaptation method to customize the EMR program to the inpatient hospital and ensure that it is acceptable to patients with SCI.

Objectives: We propose to adapt the EMR program. We will then test if this adapted program improves therapy engagement and patient outcomes in inpatient SCI units.

Methods: We will randomly assign patients to one of two groups. In one, patients will receive therapy from therapists who are trained and supervised in EMR; in the second, patients will receive therapy from therapists using standard of care (SOC) therapy (i.e., therapists doing what they usually do).

Expected Outcomes: We believe that EMR can be adapted successfully and that the manual and materials can be customized for use in inpatient SCI units. We anticipate that EMR will bring better experiences and outcomes to patients. Patients will engage more and put more effort into therapy, and they will have more positive changes in daily function, mood, and satisfaction than the SOC group.

Significance: If successful, this study will help improve therapists’ skills in working with patients, resulting in more favorable SCI outcomes.

Patient Engagement Intervention in Inpatient Spinal Cord Injury Rehabilitation, Psychosocial Research (PSR) Pilot Grant, Craig H. Neilsen Foundation, USA (10/31/18-8/30/22, NCE: 8/30/23, Award #: 542448. PI: Alex Wong)

January 30, 2023

Principal Investigator

Alex Wong, PhD

Project Type

Spinal Cord Injury

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Improving Adherence to Exercise Guidelines Using Smartphone-Based Technology and E-coaching: A Proof-of-Concept SMART-Design Study

sparmet — Mon, 30 Jan 2023 16:45:43 +0000

Improving Adherence to Exercise Guidelines Using Smartphone-Based Technology and E-coaching: A Proof-of-Concept SMART-Design Study

sparmet Mon, 01/30/2023 - 10:45 ProjectImproving Adherence to Exercise Guidelines Using Smartphone-Based Technology and E-coaching: A Proof-of-Concept SMART-Design Study /research/labs/cror/projects/improving-adherence-exercise-guidelines-using-smartphone-based-technology-and-e-coaching-proofproject-type--spinal-cord-injury

In this Spinal Cord Injury Model Systems (SCIMS) Site Specific Project, our research team will conduct a proof-of-concept project in which we use Sequential Multiple Assignment Randomized Trial (SMART) design to test an intervention to enhance adherence to exercise guidelines in individuals with spinal cord injury (SCI) by using smartphone technology, ecological momentary assessment (EMA) monitoring, and e-coaching.

EMA is a way to study people's thoughts or behavior in their daily lives by repeatedly collecting data in an individual's normal environment, at or close to the time they carry out that behavior. In this study, we use smartphone technology to gather this data. We believe strategically tailoring intervention components to users’ unique needs and preferences (based on information collected through EMA) will help improve and evaluate rehabilitation outcomes.

This study is currently recruiting participants for different parts of the study. You can participate in just one part, or both:

Participants may be asked to be part of a focus group lasting up to 2 hours to discuss app preferences to guide future app development. Participants who have a spinal cord injury may also be asked to complete exercises and other tasks on a customized smartphone app for 2 weeks and then complete a virtual interview and questionnaires. All participants will receive compensation.

To participate, you must meet the following criteria:

Have spinal cord injury diagnosis OR
Be a caregiver to someone with a spinal cord injury OR
Be a clinician who regularly treats individuals with spinal cord injury
Age 18-80 years
English-speaking
Willing to use study apps on a personal mobile device

Participants will complete one in-person visit that may last up to 5 hours. Then they will be provided customized exercises to complete over the next 6 months using either the interactive or more traditional smartphone app (groups are assigned by chance, like a flip of a coin). Up to weekly video conference coaching sessions may be added in the last 3 months. Participation is expected to last 6 months. Participants will receive compensation.

To participate, you must meet the following criteria:

Be at least 1-year post spinal cord injury diagnosis
Age 18-80 years
Not meeting spinal cord injury exercise guidelines
Willing to use study apps on a personal mobile device
No surgery or trauma in past 3 months
Not enrolled in a structured exercise program in the past 3 months

If you are interested in learning more, contact Sara Prokup at (312) 238-1355 or sprokup@sralab.org.

Co-principal investigators on this project are Alex Wong, PhD, DPhil, OT, CRC, Research Scientist in the Center for Rehabilitation Outcomes Research at Shirley Ryan С�� and Associate Professor, Physical Medicine & Rehabilitation and Medical Social Sciences at Northwestern University and Arun Jayaraman, PT, PhD, Executive Director, Technology & Innovation Hub (tiHUB) and Director, Max Näder Center for Rehabilitation Technologies & Outcomes Research at Shirley Ryan С��. Co-directors are Allen Heinemann, PhD, Director, Center for Rehabilitation Outcomes Research at Shirley Ryan С�� and
Professor, Department of Physical Medicine and Rehabilitation at Northwestern University Feinberg School of Medicine, and David Chen, MD, George M. Eisenberg Chair at Shirley Ryan С��.

Improving Adherence to Exercise Guidelines Using Smartphone-Based Technology and E-coaching: A Proof-of-Concept SMART-Design Study, Site-Specific Research Project, Spinal Cord Injury Model Systems, National Institute on Disability, Independent Living, & Rehabilitation Research (NIDILRR), USA (9/1/21-8/31/26, Total award: US$2,450,000, Award #: 90SIMS0015, Midwest Regional Spinal Cord Injury Care System (MRSCICS).

Publications

Nataletti S, Banerjee A, Macaluso R, Prokup S, Jayaraman A, Wong AWK. Developing a mobile exercise program for individuals with Spinal Cord Injury: Stakeholder perceptions of app features and implementation determinants. Disabil Health J. 2024 Jun 28:101667. doi: 10.1016/j.dhjo.2024.101667. PMID: 38964938.

June 08, 2023

Co-Principal Investigator

Alex Wong, PhD

Project Type

Spinal Cord Injury

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Breathing Low Oxygen to Enhance Spinal Stimulation Training and Functional Recovery in Persons with Chronic Spinal Cord Injury: The BO2ST Trial

Anonymous — Tue, 03 Jan 2023 16:55:43 +0000

Breathing Low Oxygen to Enhance Spinal Stimulation Training and Functional Recovery in Persons with Chronic Spinal Cord Injury: The BO2ST Trial

Anonymous (not verified) Tue, 01/03/2023 - 10:55 ProjectBreathing Low Oxygen to Enhance Spinal Stimulation Training and Functional Recovery in Persons with Chronic Spinal Cord Injury: The BO2ST Trial /research/labs/max-nader-rto/projects/bo2st-trialproject-type--spinal-cord-injury

Overview

Walking recovery is a key goal after spinal cord injury (SCI). While some patients experience spontaneous recovery due to preserved neural circuits, many struggle to achieve independent ambulation, and those who do often face persistent deficits. There is growing consensus that a single approach is insufficient to overcome these challenges, prompting the need for combined interventions.

The goal of this double-blind, placebo-controlled, block-randomized clinical trial is to investigate the efficacy and potency of daily acute intermittent hypoxia (AIH) combined with transcutaneous electrical spinal stimulation (tSTIM) and skill-based walking practice. We hypothesize that the combination of AIH, tSTIM, and walking practice will boost the efficacy of training-related gains without triggering maladaptive changes.

Subject Population

Age 18 to 70 years
Ambulatory incomplete Spinal Cord Injury C2-L2
ASIA C or D

Study Personnel

Arun Jayaraman, PT, PhD

Executive Director, Technology & Innovation Hub (tiHUB); Director, Max Näder Center for Rehabilitation Technologies & Outcomes Research

Study Partners

This study is in collaboration with the Inspire Lab led by Dr. Randy Trumbower at Spaulding Rehabilitation Hospital.

Funding Source

Department of Defense

Participation

Want to participate in this study? Fill out this interest form.

January 03, 2023

Project Type

Spinal Cord Injury

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Promoting the Psychological Health of Persons with Spinal Cord Injury

akudla — Wed, 11 May 2022 20:08:15 +0000

Promoting the Psychological Health of Persons with Spinal Cord Injury

akudla Wed, 05/11/2022 - 15:08 ProjectPromoting the Psychological Health of Persons with Spinal Cord Injury /research/labs/cror/projects/promoting-mental-health-people-sciproject-type--spinal-cord-injury

The Center for Rehabilitation Outcomes Research received 3 years of funding—covering April 2021 through April 2024—from the Craig H. Neilsen Foundation. This project aims to support the mental health of persons living with traumatic spinal cord injury (SCI).

The research team will conduct focus groups of people with SCI and healthcare providers to identify the psychological needs of the community. With guidance from an Advisory Committee composed of SCI experts, we will select priority topics for six systematic reviews of mental health issues important to adults with SCI. The researchers will share project results with doctors and therapists who are involved in SCI rehabilitation. They will also develop and share summaries of the reviews for persons living with SCI.

Project Aims and Objectives

Aim 1: Identify mental health topics that are important to people with SCI, their care partners, and their healthcare providers.
- Activities to achieve this aim include six focus groups with persons with SCI and clinicians with backgrounds in mental health and working with persons with SCI will participate in three focus groups. We will also convene an Advisory Committee consisting of persons with SCI, consumer organizations, and healthcare professionals.
Aim 2: Develop systematic reviews of identified mental health topics
- Activities to achieve this aim include The systematic reviews will describe the research evidence on effective treatment methods for psychological conditions of persons with SCI. The purpose of systematic reviews in healthcare is to provide a resource to clinicians, researchers, and public health organizations that informs both clinical care and public health decision making.
Aim 3: Share findings of systematic reviews with primary care and rehabilitation professionals who serve people with SCI
- Activities to achieve this aim include publishing findings in journals and presenting findings at professional SCI conferences.
Aim 4: Create and share consumer-friendly resources with actionable guidance about how to access resources that promote mental health and well-being following SCI.
- Activities to achieve this aim include creating visual abstract infographics that summarize the results of the systematic reviews using colorful graphics to reach persons living with SCI. The most effective infographics for translating health information to community members offer a lot of information, provide context, support familiarity, facilitate comparisons, and convey accurate meaning even when icons or images are interpreted literally.

Publications

Effectiveness of behavioral and pharmacological interventions for depressive symptoms following spinal cord injury: Findings from a systematic review

Robert Cotter, BS; Jennifer Burns, BA; Katherine Kaufman, BS; Linda Ehrlich-Jones, PhD, RN; Q. Eileen Wafford, MST\, MLIS; Allen W. Heinemann, PhD, Archives of Physical Medicine & Rehabilitation, Jan. 2024.

Psychosexual well-being following spinal cord injury: Perspectives of adults with spinal cord injury and rehabilitation clinicians

Nicole Sharf, Angelika Kudla, Jenny Burns, Linda Ehrlich-Jones, PhD, RN, Allen Heinemann, PhD. Rehabilitation Psychology, Nov., 2024.

Behavioral/Physical and Stimulation Interventions for Chronic Pain Following Spinal Cord Injury: A Systematic Review

Linda Ehrlich-Jones, PhD, RN; Elise Olsen, BA; Angelika Kudla, MS; Jennifer Burns, BA; Nicole Sharf, MA; Q. Eileen Wafford, MST, MLIS; Allen W. Heinemann, PhD. Topics in Spinal Cord Injury Rehabilitation, March, 2025

Project Team Members

Allen Heinemann, PhD

Director, Center for Rehabilitation Outcomes Research Professor, Department of PM&R, Feinberg School of Medicine, Northwestern

Linda Ehrlich-Jones, RN, PhD

Associate Director, Center for Rehabilitation Outcomes Research Research Professor, of Physical Medicine and Rehabilitation at Northwestern University's Feinberg School of Medicine

Angelika Kudla, MS, LCMHCA

Senior Project Coordinator

Jenny Burns

Research Project Manager

Funding

Promoting the Psychological Health of Persons with Spinal Cord Injury is grant funded by the Craig H. Neilsen Foundation.

Episode 13: Spinal Cord Injury and Mental Health

In the News

January 30, 2024

Center for Rehabilitation Outcomes Research

Project Type

Spinal Cord Injury, Health Services Research

Facets for Clinicians and Researchers

Research Labs & Centers

COMPLETE: Locomotor Function Following Acute Intermittent Hypoxia and Transcutaneous Electrical Spinal Cord Stimulation in Individuals with Spinal Cord Injury

Anonymous — Thu, 15 Jul 2021 16:10:20 +0000

COMPLETE: Locomotor Function Following Acute Intermittent Hypoxia and Transcutaneous Electrical Spinal Cord Stimulation in Individuals with Spinal Cord Injury

Anonymous (not verified) Thu, 07/15/2021 - 11:10 ProjectCOMPLETE: Locomotor Function Following Acute Intermittent Hypoxia and Transcutaneous Electrical Spinal Cord Stimulation in Individuals with Spinal Cord Injury /research/labs/max-nader-rto/projects/complete-locomotor-function-following-spinal-cord-stimulation-individuals-sciproject-type--spinal-cord-injury

This study is complete and is no longer recruiting subjects.

Overview

The purpose of this study is to determine if acute intermittent hypoxia therapy (AIH) combined with transcutaneous spinal cord stimulation (tSCS) during ambulation training improves locomotor function in individuals with spinal cord injury. This is a randomized, single blind, crossover trial with 3 arms:

AIH + tSCS + gait training
Sham AIH + tSCS + gait training
Sham AIH + Sham tSCS + gait training

Subject Population

Diagnosed with a spinal cord injury below level C2 - ASIA Impairment Scale Grade A-D
18 years of age or older
At least 6 months post spinal cord injury
Paraplegia or tetraplegia secondary to a single spinal cord injury
Able to provide informed consent
Not currently receiving regular physical therapy services

Study Personnel

Arun Jayaraman, PT, PhD

Executive Director, Technology & Innovation Hub (tiHUB); Director, Max Näder Center for Rehabilitation Technologies & Outcomes Research

Study Partners

Milap Sandhu, PT, PhD

Research Scientist II, Shirley Ryan С�� Assistant Professor of Physical Medicine and Rehabilitation, Northwestern University

Funding Source

Shirley Ryan С��-Craig H. Nielsen Foundation Infrastructure Grant

Shirley Ryan С�� Catalyst Grant Program

November 29, 2018

Project Type

Spinal Cord Injury

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Research Labs & Centers

Use of a Micro-Processor Controlled Knee-Ankle-Foot Orthosis Compared to Traditional Rehabilitation in Spinal Cord Injury

Anonymous — Tue, 29 Sep 2020 20:41:26 +0000

Use of a Micro-Processor Controlled Knee-Ankle-Foot Orthosis Compared to Traditional Rehabilitation in Spinal Cord Injury

Anonymous (not verified) Tue, 09/29/2020 - 15:41 ProjectUse of a Micro-Processor Controlled Knee-Ankle-Foot Orthosis Compared to Traditional Rehabilitation in Spinal Cord Injury /research/labs/max-nader-rto/projects/micro-processor-controlled-knee-ankle-foot-orthosisproject-type--spinal-cord-injury

Overview

People with incomplete spinal cord injury (SCI) often experience weakness in their legs. Use of an orthotic device may help them move more easily by providing them support.

The C-Brace from Ottobock is one type of next generation micro-processor controlled knee-ankle-foot orthosis (KAFO) that allows users to have more control during the different phases of walking (when the foot first leaves the ground to when it touches back down), offering stumble recovery and reduction in falls. It differs from traditional KAFOs in that it has a micro-processor (computer) that controls the bending and straightening of the knee joint. These features may increase independence in activities of daily living and improve walking safety and stability. If realized, these functions may help people that sustain SCI to increase community mobility and participation.

The purpose of this study is to evaluate the potential of the C-Brace to improve the functional mobility and quality of life in individuals with lower extremity impairments due to SCI when compared to traditional rehabilitation methods. Participants will be randomized into one of two groups: one that uses the C-Brace, or a traditional care group where participants will receive traditionally recommended orthotics as deemed appropriate by an orthotist. Participants in both groups will complete a variety of outcome measures measuring functional mobility, balance, quality of life, and community participation levels.

Subject Population

Be maximum 24 months post spinal cord injury diagnosis
Ability to wear and use orthotic bracing for lower extremity instability
Prescription or need for orthosis
Ages 18-80 years

Study Team Personnel

Arun Jayaraman, PT, PhD

Executive Director, Technology & Innovation Hub (tiHUB); Director, Max Näder Center for Rehabilitation Technologies & Outcomes Research

Funding Source

Ottobock

Participation

Want to participate in this study? Fill out this interest form.

June 01, 2022

Posted By Sheila Burt

Project Type

Spinal Cord Injury, Outcomes

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Research Labs & Centers

Intracortical Inhibition in Humans with Spinal Cord Injury

ekizziar — Thu, 23 Apr 2020 02:18:31 +0000

Intracortical Inhibition in Humans with Spinal Cord Injury

ekizziar Wed, 04/22/2020 - 21:18 ProjectIntracortical Inhibition in Humans with Spinal Cord Injury /research/labs/neuromodulation/projects/intracortical-inhibition-humans-spinal-cord-injuryproject-type--spinal-cord-injury

Project Summary:

This study investigates the intracortical inhibition in humans with cervical spinal cord injury. We particularly aim to understand the inhibitory mechanism for the control of upper arm muscles to further promote rehabilitation protocol.

Contact Information:

Please contact Hoda Salsabili (hsalsabili@sralab.org) for more details!

April 22, 2020

Contact Information

hsalsabili@sralab.org

Project Type

Spinal Cord Injury

С�� Reference

Arms + Hands Lab

Innovation Center Reference

Center for Spinal Cord Innovation

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Spasticity Assessments Research Project

ekizziar — Thu, 23 Apr 2020 01:45:37 +0000

Spasticity Assessments Research Project

ekizziar Wed, 04/22/2020 - 20:45 ProjectSpasticity Assessments Research Project /research/labs/neuromodulation/projects/spasticity-assessments-research-projectproject-type--spinal-cord-injury

Project Summary:

Spasticity is one of the most common symptoms present in humans with spinal cord injury (SCI), however, its clinical assessment remains underdeveloped. The purpose of the study was to examine the contribution of passive muscle stiffness and active spinal reflex mechanisms to clinical outcomes of spasticity after SCI. It is important that passive and active contributions to increased muscle stiffness are distinguished to make appropriate decisions about anti-spastic treatments and to monitor its effectiveness. To address this question, we combined biomechanical and electrophysiological assessments of ankle plantarflexor muscles bilaterally in individuals with and without chronic SCI. We performed slow and fast dorsiflexion stretches of the ankle joint to measure passive muscle stiffness and reflex-induced torque using a dynamometer instrumented with electromyographic and real-time online feedback system.

April 22, 2020

Contact Information

bchen03@sralab.org

Project Type

Spinal Cord Injury

С�� Reference

Arms + Hands Lab

Innovation Center Reference

Center for Spinal Cord Innovation

Facets for Clinicians and Researchers

Research Labs & Centers

Spinal Cord Injury

Biomarkers for Recovery Following Spinal Cord Injury

Biomarkers for Recovery Following Spinal Cord Injury

Biomarkers for Recovery Following Spinal Cord Injury

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Facets for Clinicians and Researchers

Using a Health Technology Assessment Framework for Evaluating the Utilization and Efficiency of Wearable Exoskeleton for Spinal Cord Injury Rehabilitation

Using a Health Technology Assessment Framework for Evaluating the Utilization and Efficiency of Wearable Exoskeleton for Spinal Cord Injury Rehabilitation

Using a Health Technology Assessment Framework for Evaluating the Utilization and Efficiency of Wearable Exoskeleton for Spinal Cord Injury Rehabilitation

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What is the goal of this project?

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What are some of the results?

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Facets for Clinicians and Researchers

Patient Engagement Intervention in Inpatient Spinal Cord Injury Rehabilitation

Patient Engagement Intervention in Inpatient Spinal Cord Injury Rehabilitation

Patient Engagement Intervention in Inpatient Spinal Cord Injury Rehabilitation

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Principal Investigator

Project Type

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Facets for Clinicians and Researchers

Improving Adherence to Exercise Guidelines Using Smartphone-Based Technology and E-coaching: A Proof-of-Concept SMART-Design Study

Improving Adherence to Exercise Guidelines Using Smartphone-Based Technology and E-coaching: A Proof-of-Concept SMART-Design Study

Improving Adherence to Exercise Guidelines Using Smartphone-Based Technology and E-coaching: A Proof-of-Concept SMART-Design Study

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Publications

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Co-Principal Investigator

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Facets for Clinicians and Researchers

Breathing Low Oxygen to Enhance Spinal Stimulation Training and Functional Recovery in Persons with Chronic Spinal Cord Injury: The BO2ST Trial

Breathing Low Oxygen to Enhance Spinal Stimulation Training and Functional Recovery in Persons with Chronic Spinal Cord Injury: The BO2ST Trial

Breathing Low Oxygen to Enhance Spinal Stimulation Training and Functional Recovery in Persons with Chronic Spinal Cord Injury: The BO2ST Trial

Overview

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Subject Population

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Study Partners

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Participation

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Promoting the Psychological Health of Persons with Spinal Cord Injury

Promoting the Psychological Health of Persons with Spinal Cord Injury

Promoting the Psychological Health of Persons with Spinal Cord Injury

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Project Aims and Objectives

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Publications

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Effectiveness of behavioral and pharmacological interventions for depressive symptoms following spinal cord injury: Findings from a systematic review

Psychosexual well-being following spinal cord injury: Perspectives of adults with spinal cord injury and rehabilitation clinicians

Behavioral/Physical and Stimulation Interventions for Chronic Pain Following Spinal Cord Injury: A Systematic Review

Project Team Members

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Funding

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Promoting the Psychological Health of Persons with Spinal Cord Injury is grant funded by the Craig H. Neilsen Foundation.

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